A class of widely used drugs against nausea and vomiting is associated with an increased risk of ischemic stroke, according to study of French scientists.
Patients taking antidopaminergic antiemetics to treat nausea and vomiting caused by migraine, anti-cancer chemotherapy and radiation therapy, or other causes, are more than three times more likely to develop ischemic stroke than those who do not. French scientific research.
Researchers at the University of Bordeaux, led by Dr. Ann Benar-Laribier, published in the British Medical Journal (BMJ), analyzed data from 2,612 patients with a mean age of 72 years who had a stroke and another 21,859 people. (the control group).
It was found that among those who had a stroke, almost half (48%) had taken an antiemetic drug (domperidone, metopimazine or metoclopramide) at least once in the last 14 days before the stroke. Men were found to have the highest risk (by 3.6 times) of stroke after taking antiemetic drug.
Like antipsychotics, these antiemetics block the action of dopamine in the brain. Antipsychotics have also been linked to previous studies with increased risk ischemic stroke.
All three of the above drugs were found to increase the risk of stroke, especially after the initial doses (comparatively less, by 2.5 times domperidone, while the other two by 3.5 to 3.6 times). Their effect on blood circulation to the brain probably explains this correlation.
“It’s not the first side effects of these drugs to be identified and they may not be the most serious, but they are something that prescribers should keep in mind,” said pharmacologist-epidemiologist Antoine Parriente.
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