According to a major new study, obese people can help lose up to 24 kg (almost 4 stones).
A drug called tirzepatide is a weekly injection of ghrelin, a hormone that regulates our appetite.
This drug (originally designed to treat diabetes) significantly reduces the desire to eat, thereby reducing the number of calories a person burns.
It was developed by the American pharmaceutical giant Lily and has the potential to revolutionize the treatment of obesity.
According to a study published in the New England Journal of Medicine, people who received weekly injections of the drug lost (on average) 22.5% of their body weight. However, side effects such as diarrhea and vomiting have been reported.
More than 2,500 people from nine countries participated in a double-blind randomized trial. Volunteers with an average weight of 105 kg (230 lb) were instructed to inject low dose (5 mg), medium dose (10 mg), high dose (15 mg), or placebo.
The results that lasted 72 weeks showed that the most effective dose of the drug was the highest.
“Tirzepatide is the first investigational drug to lose more than 20% of average body weight in Phase 3 trials, strengthening our belief in the potential to help obese people,” said MD and Vice President of Products, Jeff Emic. Development in Lily.
Of course, the higher the dose, the worse the side effects. In addition to diarrhea and vomiting, participants reported nausea and constipation.
However, unlike obesity surgery, which permanently changes a person’s diet, weight-loss medications can be stopped at any time.
Obesity may not meet the same criteria as other conditions, despite physical, psychological, and metabolic health effects that can include high blood pressure, heart disease, cancer, and reduced survival. It is a common chronic disease. Louis J. Aaron, an obesity expert.
Lily expects the drug to hit the market in the next few years, but says further testing is needed to see if it also helps prevent type 2 diabetes.
Obesity in the UK
According to the World Health Organization, obesity has almost tripled worldwide since 1975.
This is still a problem in the UK, with the NHS reporting that by 2021, more than a million people were hospitalized due to obesity.
Today, 64% of adults are overweight or obese, but the number is increasing year after year.
According to Cancer Research analysis, this will increase by another 10-7 (71%) over 20 years.
Of these, 21 million are obese, which represents 10-4 (36%) of all adults.
Source: Metro
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