Scientists believe they will be the best defense against future pandemics.
Canadian scientists who compared two different alternative vaccine delivery systemsconfirmed that the inhaled vaccines in aerosol form provide better protection and stronger immunity than vaccines in form nasal spray.
While nasal sprays primarily reach the nose and to neckinhaled pass the nasal passage and allow the vaccine droplets to penetrate deep into the lungs, where they can elicit a broader immune response, according to the new research.
McMaster University researchers, led by Dr Dr. Matthew Miller, specialist in pandemic viruses, who published in the immunology journal Frontiers in Immunology, used a tuberculosis vaccine to compare the two alternative delivery methods (versus injectable vaccines), confirming that administration in the lungs it is more effective and therefore preferable.
“Upper respiratory infections tend not to be serious. But when in infections caused by viruses like the flu or SARS-CoV-2, the virus gets deep into the lungs, that’s when you get really sick. The immune response that’s created, when the vaccine is delivered deep into the lungs, it is much stronger than when the vaccine material stays in the nose and throat,” Miller said.
About 6.3 million people have died during it Covid-19 pandemic and respiratory infections remain a major cause of illness and death worldwide. That is why there is an urgent need to develop vaccines that will not be given intravenously, but directly in the respiratory tract. The new study provides strong evidence that this is better done orally than through the nose.
Read the study in English here.
Already McMaster scientists have developed a unique inhaled form of vaccine against Covid-19, believing that inhaled vaccines will be the best defense against future pandemics. A phase 1 clinical trial is underway to evaluate the inhaled vaccine in healthy adults who have previously had two or three doses of mRNA vaccine against the coronavirus.
Nasal flu shots have been shown to be very effective in children, but a lot less so in adultsmaking injectable flu shots the most popular choice for seasonal flu vaccination so far.
RES-EMP
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