Hypertensive disorder of pregnancy includes pre-eclampsia, eclampsia and hypertension, which can cause complications in pregnancy.
A disorder that triggers abnormally high blood pressure in a pregnant woman is associated with an increased chance of the child dying early from birth through adulthood, a major new study shows.
Hypertensive disorder of pregnancy includes pre-eclampsia, eclampsia and hypertension, which can cause complications in pregnancy.
The disorder affects up to 10% of pregnancies worldwide and is one of the leading causes of maternal and neonatal morbidity and mortality. It has also been associated with various conditions later in childhood, such as metabolic syndrome (combination of diabetes, hypertension and obesity), autoimmune diseases and neurodevelopmental or psychiatric disorders.
The researchers from China and Denmark, led by biostatistics specialist Dr. Yongfu Yu of the School of Public Health at Fudan University in Shanghai, who published the relevant publication in the British Medical Journal (BMJ), analyzed data in 20-year depth for approximately 2.43 million people, of whom 4.2% had been exposed to a prenatal hypertensive disorder (2.8% to preeclampsia and 1.4% to hypertension).
It found that premature mortality from any cause (by age 41) was 26% higher in children exposed as fetuses to gestational hypertensive disorder. In particular, the risk was increased by 29% in the case of pre-eclampsia, 188% for eclampsia and 12% for hypertension of the pregnant mother.
Children whose mothers developed severe and early-onset preeclampsia had a more than six-fold increased risk of death, especially if the mother had a history of diabetes or low educational level. No correlation was found between maternal hypertensive disorder of pregnancy and fatal cancer in the child.
The researchers emphasized the need for further study to explore the biological mechanisms between maternal pregnancy disorder and early child mortality.
RES-EMP
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