The scientists identified 618 proteins associated with 19 different types of cancer. These included 107 proteins in a group of people whose blood was collected at least seven years before diagnosis and predicted the disease.
Proteins in the blood that could warn people of cancer more than seven years before it is diagnosed have been discovered by researchers in two studies, which were funded by the British research organization “Cancer Research UK” and published in the journal “Nature Communications”.
The scientists identified 618 proteins associated with 19 different types of cancer. These include 107 proteins in a group of people whose blood was collected at least seven years before diagnosis.
The team discovered that these proteins could be involved in the very early stages of cancer, so it could be prevented, and they believe that some of these proteins could be used to detect cancer much earlier than is currently possible .
In the first study, researchers analyzed blood samples from the UK Biobank, which were taken from more than 44,000 people, including more than 4,900 people who were subsequently diagnosed with cancer.
Using the method of proteomics, where all the proteins in a biological sample are analyzed, the scientists analyzed a total of 1,463 proteins from a single blood sample from each person. They compared the proteins of people diagnosed and those not diagnosed with cancer to look for differences between them. They also identified 182 proteins that differed in the blood three years before the cancer diagnosis.
In the second study they examined genetic data from more than 300,000 cancer cases to investigate in depth which blood proteins are involved in cancer development and could be the target of new treatments. They found 40 proteins in the blood that affect the risk of developing nine different types of cancer. However, while changing these proteins can increase or decrease a person’s chances of developing cancer, scientists have also found that in some cases this can lead to unwanted side effects.
The researchers stress that they will need to do further research to discover the exact role these proteins play in cancer development, which of the proteins are the most reliable to test, which tests could be developed to detect the proteins in clinic and which drugs could target these proteins.
Source :Skai
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