Gray hair, wrinkles, wear – responsible for all this is AP2A1 protein. So could science put a brake on diseases due to old age?
“The garrison is coming only” … For this reason humanity has been looking for centuries -old sources of youth, elixir or resort to anti -aging products that promise eternal youth
Researchers from Japan have now discovered a protein responsible for the aging process. If it is blocked, cellular aging may slow down or even reversed.
People could not only live longer, but also delay wear and tear: age -related diseases, such as osteoporosis, heart disease, certain types of cancer or neurodegenerative diseases, could also be mitigated. Some diseases may even be possible to prevent them before even the first symptoms occur.
The AP2A1 protein and the action of
In the process of aging, cells are gradually becoming increasingly inactive. They are no longer divided, nor do they die. This condition is known as cellular aging.
The aging cells are not only older, as their name says, but also significantly larger. This is probably due to proteins that thicken the so -called fibers in the cell walls, making cells less agile.
“One fascinating element is that the fibrous structures in aging cells are much thicker than in young cells, which suggests that proteins in these fibers enhance their size,” explains study author Pirauan.
A protein is hidden from behind: the researchers managed to identify the AP2A1 (Adaptor Protein Complex 2, Alpha 1 Subunit), which mainly appears in aging cells.
“The suppression of AP2A1 in largest cells reverses the aging process and promotes cell renewal, while AP2A1’s enhanced presence in young cells accelerates aging,” said Sinji Degucci, head of the study.
It is certain that it will take time for these findings to find a practical application. However, in addition to developing anti -aging products, this discovery could contribute substantially to the extension of life and to improve health. This is because it is not only concerned with the typical symptoms of aging, but faces the causes of the cells that due to the aging process.
Source:
AP2A1 Modulates Cell States Between Senescence and Rejuvenation
https://www.sciencedirect.com/science/article/PII/S0898656825000294?via%3dihub
Source: Skai
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