In the latest data on hepatitis in children refers to Professor of Health Policy at Imperial College and the London School of Economics and Political Science (LSE), Elias Mosialos, noting among other things that “Based on the data we have so far, the risk of pediatric hepatitis of unclear etiology worldwide is not high”.
Mr. Mosialos mentions in detail the following:
“With the appearance of her incidents smallpox of monkeys, media reports on pediatric hepatitis of unexplained etiology have decreased. So let’s see what we know.
From 5 April to 26 May, 650 possible cases of acute hepatitis of unknown etiology in children have been reported to the WHO, and the etiology remains under investigation. In addition, 99 additional cases are pending registration. The majority of reported cases (58%) are from WHO European Region (22 countries), with 222 (34%) cases from the United Kingdom of Great Britain and Northern Ireland alone. 216 cases were recorded in the USA.
According to previous data, and compared to previous reports of acute hepatitis of unknown etiology in children, cases have a more severe clinical picture and a higher rate develops acute liver failure. However, it has not been determined whether (and in which countries) the cases detected are above the expected levels. Of the 650 cases reported to the WHO, at least 38 (6%) children needed transplants and unfortunately nine deaths (1%) were also recorded.
Let me recall some data from the latest Joint Surveillance Report of the WHO Regional Office for Europe and the European Center for Disease Prevention and Control (ECDC) on cases from EU / EEA countries reported through the European Monitoring System (TESSy) , until May 20, 2022:
1. Three quarters (75.4%) of the cases were under 5 years old.
2. There are data on 156 cases regarding their admission to the hospital. Of these, 22 (14.1%) were admitted to an intensive care unit.
3. Of the 117 reported cases, 14 (12%) have undergone a liver transplant.
4. A total of 181 cases were tested for adenovirus of any sample type, of which 110 (60.8%) were positive. The positivity rate was higher when whole blood samples were analyzed (69.5%).
5. Of the 188 cases examined for coronavirus, 23 (12.2%) were positive. Serological results for ex-coronavirus disease were available for only 26 cases, of which 19 (73.1%) were positive.
However, as I said, the reason remains under investigation. But they are still missing
1. Histopathological reports of cases requiring transplantation
2. The serological results for former coronavirus disease
These would be expected to be prioritized, given that some countries had no evidence of adenovirus, while some had incidents they had history of coronavirus disease. In England, for example, we would expect them to be even more readily available, given that HIV-positive children under 6 were up ~ 47% by April, according to the UKHSA report.
Let me remind you here that that Israelthe Austria and the Italy treat these childhood hepatitis as a complication due to a previous coronavirus infection.
“Based on the data we have so far, the risk of childhood hepatitis of unclear etiology worldwide is not high.”
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