This development paves the way for male couples to have their own children rather than through adoption – The first eggs were created from male mouse cells, paving the way for babies with two biological fathers
A Japanese researchers announced that he had created viable eggs from the cells males of mice. This is the first laboratory creation of mammalian oocytes from male cells.
The next – not easy – step will be to pursue something similar to human cells, as there is, among other things, the risk of causing unwanted genetic changes.
The research, located in early stages also, it concerns the conversion of male XY chromosomes into female XX. This development paves the way for male couples to have their own children and no longer through adoption.
The announcement was made by the professor Katsuhiko Hayashi of her University Osaka, who enjoys international prestige in his field, at a conference of the Francis Crick Institute of Genetics in London, according to BBC and The Guardian.
Other scientists appeared cautiousi. Professor George Daly of the Harvard Medical School, USA, pointed out how it will be a long time before society is confronted in practice with the choice of babies from two fathers.
Hayashi himself stated that his work is far from over primary stage. The eggs he created are of low quality and the technique cannot currently be used safely in humans. However, he expressed optimism that today’s difficulties may have been overcome in ten years and that a reproductive technique for same-sex couples will eventually become available.
“If people want it and society accepts such technology, I agree,” said the Japanese scientist. However, he appeared hesitant about the method being used by a man to create a baby from his own sperm and artificially created eggs. “Technically this is possible,” he said. “But I’m not sure if it’s something safe or socially acceptable at this stage.”
The method involves taking a skin cell from a male rodent and turning it into a pluripotent stem cell that can turn into other types of cells. These cells as males have XY chromosomes. Then the researchers they delete the Y chromosome of these cells, double the X, and eventually “glue” the two X’s together. This allows the stem cell to be reprogrammed to become an egg.
The cells are then grown into an ovarian organoid that mimics conditions in mouse ovaries. When the eggs were fertilized with sperm, 600 embryos were created, from which seven mice were eventually born (a low success rate of about 1%). However, these rodents were seen healthy and had a normal lifespan, while they themselves had offspring.
Technique can also help infertile couples intersex, in which the woman cannot produce her own eggs due to a serious problem such as Turner syndrome (where one copy of the X chromosome is missing). But it will be years until (and if) such a new infertility treatment becomes available.
Other scientists consider that the time horizon of the decade is overly optimisticconsidering that viable human eggs from female cells have not yet been created in the laboratory.
Source :Skai
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