Significant discovery in Scotland illuminates how the bowel cancer is spread.
Scientists have found that cancer cells have the ability to convert to other types of cells, such as skin or muscle, thereby enhancing their strength and ability to metastases to other organs.
Cancer Research UK Scotland Center and the University of Edinburgh University has shown that the process called “cell plasticity”, during which this conversion is happening, is a key factor in the aggression of the disease.
Specifically, intestinal cells acquire more durable cells, such as keratinocytes or muscles.
In addition, the gene was examined ATRXthe absence of which is linked to an increase in metastases, mainly to the liver, the lymph nodes and the diaphragm. The findings were based on samples of human tissues and mice.
As bowel cancer increases rapidly in young adults, especially in women in Scotland and England, scientists emphasize the importance of understanding the mechanisms of the disease to develop more effective therapies.
The study, published in Nature And funded by the Medical Research Council and the European Research Council, it is part of the CRC-Stars program, featuring over 40 experts in bowel cancer.
Source :Skai
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