An important discovery, which may prove extremely important for the treatment of modern world diseases and for all Mediterranean olive oil producing countries, has recently been made by Greek and Turkish scientists, studying the ingredients of excellent virgin olive oil.

After two years of cooperation they managed to apply to the laboratory an innovative method, which identifies the presence of the “3.3 Dimethyl-1-Butanol” ingredient (3.3 dimethyl 1-butanol, hereinafter and now DMB) in the extra virgin olive oil, of a beneficial to the health of the human body, which It works against harmful compounds (TMA and TMAO), which are associated with the challenge atherosclerosis and the appearance of inflammation in various cardiovascular disease.

So far in international literature there are scarce and mainly fragmentary references to the importance of DMB and no method has been published, which is safely and safely identifying the DMB concentrations in excellent virgin olive oil.

As participants noted in the study, they are ‘The first time a laboratory is confirmedbased on a credible scientific method, the presence of the DMB ingredient in olive oil and determine its prices with impressive results. “

At the end of June, the international scientific team, consisting of 4 Greeks, 3 Turks and one Canadian, of Iranian origin (and specifically: Rifat Gimatdin, Hasan Yavuz Gören, Nikos Sakellaropoulos, Konstantinos Kiritsakis, Charalampos Anousakis, Fereidoon Shahaidi, Ahmeti Ceyhan Gören), led by Emeritus Professor of the International University of Greece Apostolos Kiritsakis, published in the international scientific and prestigious journal Journal of Food Bioactives the impressive results of the pioneering study, under the general title “Quantification of 3,3-Dimethyl-1) Novel Method ».

This research has at the same time a definitive response to two basic, to date, questions of the global scientific community of olive oil: “If there is really DMB in olive oil” and “if this ingredient gives it even greater value”.

Finally, in the last two years, on his initiative and “in collaboration with the well -known and award -winning international awards in olive oil and olive tree George Sakellaropoulos from Sparta and also well -known Professor Ahmet Ceyhan Gören of the University of Gebze, Samples of organic olive oil from Greece and Turkey, “said DIPAE Professor A. Kiritsakis.

“We are the first to determine the prices of the DMB ingredient,” commented Mr Kiritsakis, adding: “We are now led to the next step: to see the effectiveness of this ingredient, which is separate and not phenol … the ingredient we have identified and identified it seems to be able to intercede with the action and it seems to be able to interfere with such as atherosclerosis and cardiovascular disease. “

What have shown studies for TMA and TMAO

Trying to highlight the importance of olive oil and the key role of DMB in the treatment of TMA and the TMAO derivative, members of the Greek -Turkish scientific team note in the same study “the crucial nutritional role that this has been playing in Mediterranean culture for thousands of years”.

Numerous studies have highlighted olive oil as an important source of antioxidants based on its phenolic profile, which includes phenolic acids and alcohols, polyphenols, lignans, securidoids, olive oil and olive oil. The biological effects of the ingredients of olive oil include protection from cardiovascular disease, anti-inflammatory action and neurotheal and endothelial protection.

Regarding TMA, scientists emphasize that it “is produced by the intestinal microbiome, derived from foods such as red meat and then absorbed into the bloodstream and oxidized to TMAO in the liver. TMAO seems to facilitate the development of atherosclerosis in animal models that feed on a diet rich in animal proteins. TMAO, a metabolite dependent on intestinal microflora, is associated with inflammatory diseases, such as atherosclerosis, whose immunological processes reflect those of rheumatoid arthritis (RA).

Olive oil antioxidants, cardiovascular, cancer

“Studies have been conducted both in vitro and in vivo in humans and animals to better understand the metabolism and bio -visibility of the olive oil phenolic compounds. Antioxidants from olive oil are not only absorbed by the body, but can also be attached to the digestive tract mucosa, contributing to its health benefits. Consuming excellent virgin olive oil (EVOO), through diet, is associated with the prevention of cardiovascular disease (CVD) and certain types of cancer. This is linked to the balanced composition of fatty acids, with the main ingredient is oleic acid, as well as the presence of secondary compounds, such as polar phenols, tocopherols and sterols. These features make olive oil a high quality functional food … “.

DMB guide to new strategies to prevent and treat diseases

“… the metabolite TMAO dependent on the intestinal microbiome is associated with a poor prognosis in the pulmonary arterial hypertension,” the study notes, while quoting the case of researchers at Cleveland, Ohio, USA and the University of California, Los Angeles, USA, USA, DMB safely suspended atherosclerosis (the well -known plaque accumulation in the arteries) and significantly reduced TMAO production. A preclinical study by Wang (2015) showed that DMB reduced TMAO levels, inhibiting atherosclerosis in animal models. Thus, DMB is one of the oral trimethylamine (TMA) and TMAO. Metabolites derived from the intestinal microbiome, including TMMA, TMAO and short chain fatty acids, have been linked to hypertension. “

“… DMB treatment during pregnancy and lactation has been shown to relieve hypertension, providing information on DMB’s therapeutic potential as a microbiome metabolite to prevent hypertension of developmental etiology. Researchers have suggested that if future studies in people show similar results, DMB could lead to new strategies for prevention or even the treatment of heart disease and stroke, two of the main causes of death worldwide. TMAO has also been linked to aging, cognitive impairment and other brain disorders. A 2021 study provided for the first time immediate evidence that repetitive exposure to DMB produces significant impact on social domination of adult mice without any effect on stress, depression -like behavior or memory formation. “