One in 500 men has an extra X or Y chromosome – What is the risk to his health

by

The X and Y chromosomes determine the sex. Men have an X and a Y, while women have two X. But what about those who have an extra?

About one in 500 men, twice as many as previously thought, have a body additional X or Y sex chromosome – most without even knowing it – which puts them in increased risk for various diseases such as type 2 diabetes, atherosclerosis and thrombosis, according to British scientists.

The researchers at the Universities of Cambridge and Exeterwho made the relevant publication in the journal Genetics and Medicine, analyzed genetic data from 207,067 men aged 40 to 70 years, including 356 carrying an extra chromosome X (the 213) or an extra Y chromosome (the 143).

The X and Y chromosomes determine the sex. Men have an X and a Y, while women have two Xs. , not to know it. The study found that 23% of men with CHY and only 0.7% of men with CHY had already been diagnosed with the extra chromosome.

Relating genetic data to each individual’s medical records, Researchers have found that XXX men are much more likely to have reproductive problems and infertility, as among other things they are three times more likely to be late adolescents and four times more likely to be childless. These men with extra X chromosomes have significantly lower testosterone levels than normal men (XY). On the other hand, men with extra Y (HYY) have normal reproductive function, while they tend to be taller than children, but otherwise have no other distinct characteristics.

However, both FYCs and FYCs are at greater risk for other health problems. They are three times more likely to have type 2 diabetes, six times more likely to have venous thrombosis, three times more likely to have pulmonary embolism and four times more likely to have chronic obstructive pulmonary disease (COPD). Scientists are not sure why the presence of an extra chromosome increases health risks or why the risks are just as high, regardless of whether the extra chromosome is X or Y.

Ken Ong, professor of pediatric endocrinology at the Cambridge Epidemiology Unit, said he was surprised that the extra chromosome was more common than expected. He said: “Genetic testing can detect chromosomal abnormalities relatively easily, so it would be helpful if more men were tested for CKD or CFS. “is something that could possibly lead to more timely interventions to avoid various diseases.”

Previous studies had found that approximately one in 1,000 women has an extra X chromosome (hence they are XXX), which may result in their faster development until adolescence, but also delayed language development, as well as a lower IQ.

You May Also Like

Recommended for you