Written by Christos Iatou, Nephrology Center Director (Center for Diagnosis, Therapy & Research of Kidney Diseases) HYGEIA & Director of Artificial Kidney Unit, MITERA Clinical
It is now evident by the bibliographic data that a series of factors are associated with renal attack that in its evolution leads to Chronic Kidney Damage/Disease (HNN). These factors include diabetes mellitus, hypertension, obesity, old age (> 60 years), the existence of cardiovascular disease, the existence of a family history of kidney disease, the birth of very premature and lucrative child, Analgesic drugs or reckless intake of non -steroidal anti -inflammatory drugs – which is easily taken for rheumatic aches or lumbarhogealgia or taking nephrotoxic antibiotic drugs, etc.), nephrolithia, e.g. etc.), spirals, hereditary diseases (eg kidney polycystic disease, etc.), smoking, climate change and air contamination.
The CNN is found in about 10% of the general population worldwide, based on existing epidemiological data, which means that worldwide about 800,000,000 patients (in Greece about 1,000,000 patients) suffer from mild as a severe form of CKD (that is, from the stage that can only be detected by the blood. clearance, that is, dialysis or peritoneal clearance).
This disease is a very serious problem for public health because it is associated with increased morbidity and mortality, and it is noteworthy that many of the sufferers have no serious symptom even in the advanced stages of it (ie in advanced disease/ kidney disease) clearance.
The main symptoms of the disease They are non -specific and include weakness, malaise, loss of appetite, nausea or vomiting, sleep disorders, reduced clarity, itching (itching), cramps or changes in composition and quantity of urine, while more severe symptoms that are usually concerned about the patient, fluid retention.
In the early stages of the disease, some of the above symptoms begin to occur at a very slow rate that are not adequately evaluated by patients and due to the non -specialty of symptoms, the diagnosis is made when an increased value of urea and especially blood creatinine is found during laboratory testing.
But because creatinine is produced in the muscles and its value depends on the muscle mass of the person, age and sex, more accurate indicator for the diagnosis of HNN It is by using the price of blood creatinine and the CKD-EPI type, calculating the rate of glomerular filtration (of EGFR, as it is called) by the laboratory or treating physician. Another important test for the diagnosis of the disease is the general urine, in which blood (red blood cells or hemoglobin) can be detected, albeit in a small amount, or album (protein). The most sensitive test (test) for the detection of the latter in the urine is to determine the speech of albumin/creatinine in a sample of morning urine (reason greater than 30 millmines of albumin/gram of creatinine or even greater).
Given that studies have shown that about 25% and 15% of diabetic and non -diabetic patients, respectively, will deteriorate renal function within the next two years of the diagnosis of even mild/moderate renal damage (moderate), it can be completely clear that early diagnosis and therapeutic of evolution or reversal of damage, avoiding extraterrestrial purification and essentially kidney salvation.
Finally, it should be noted that in addition to the above -mentioned simple laboratory testing that everyone should be submitted for the early diagnosis of CKD, (especially when there is one of the mentioned factors that is blamed for CKD), an important role in securing the health of the kidneys, and diabetes mellitus are the most important factors that are blamed for kidney damage).
But the most important role in the early diagnosis of CKD and kidney salvation, the state can play by implementing a diagnostic test program (the so -called Screening program), in a targeted general population (targeting is needed due to high costs in implementation of screening to the general population). Cardiovascular patients and especially when there is a family history of kidney disease.
Source :Skai
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